Novel gallium(III) complexes containing phthaloyl derivatives of neutral aminoacids with apoptotic activity in cancer cells

The reaction of N-phthaloylglycine and N-phthaloyl-dl-alanine with trimethylgallium (1:1) yielded the dinuclear complexes [Me2Ga(μ-O2CCH2N(CO)2C6H4)]2 (1) and RS-[Me2Ga(μ-O2CCHMeN(CO)2C6H4)]2 (2), respectively. The molecular structure of 2 was determined by X-ray diffraction studies. The cytotoxic activity of the organogallium(III) complexes (1 and 2) was tested against human tumour cell lines 8505C anaplastic thyroid cancer, A253 head and neck...