Modulation of innate immunity by African Trypanosomes

SUMMARY The experimental studies of Brucei group trypanosomes presented here demonstrate that the balance of host and parasite factors, especially IFN- γ GPI-sVSG respectively, and the timing of cellular exposure to them, dictate the predominant MP and DC activation profiles present at any given time during infection and within specific tissues. The timing of changes in innate immune cell functions following infection consistently support the...