A Variant in MCF2L Is Associated with Osteoarthritis
Abstract
Osteoarthritis (OA) is a prevalent, heritable degenerative joint disease with a substantial public health impact. We used a 1000-Genomes-Project-based imputation in a genome-wide association scan for osteoarthritis (3177 OA cases and 4894 controls) to detect a previously unidentified risk locus. We discovered a small disease-associated set of variants on chromosome 13. Through large-scale replication, we establish a robust association with SNPs...
Paper Details
Title
A Variant in MCF2L Is Associated with Osteoarthritis
Published Date
Sep 1, 2011
Volume
89
Issue
3
Pages
446 - 450
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