Evaluation of beta-cell sensitivity to glucose and first-phase insulin secretion in obese dogs

To compare beta-cell sensitivity to glucose, first-phase insulin secretion, and glucose tolerance between dogs with naturally occurring obesity of > 2 years' duration and lean dogs.17 client-owned obese or lean dogs.Frequently sampled IV glucose tolerance tests were performed with minimal model analysis on 6 obese dogs and matched controls. Glucagon stimulation tests were performed on 5 obese dogs and matched controls.Obese dogs were half as...