Closure of multiple types of K+ channels is necessary to induce changes in renal vascular resistance in vivo in rats

Inhibition of K+ channels might mediate renal vasoconstriction. As inhibition of a single type of K+ channel caused minor or no renal vasoconstriction in vivo in rats, we hypothesized that several classes of K+ channels must be blocked to elicit renal vasoconstriction. We measured renal blood flow (RBF) in vivo in anesthetized Sprague–Dawley rats. Test agents were infused directly into the renal artery to avoid systemic effects. Inhibition of...