‘Sensing’ autoimmunity in type 1 diabetes
Abstract
Type 1 diabetes (T1D) results from autoimmune-mediated loss of insulin-producing β-cells. Recent findings suggest that the events controlling T1D development are not only immunological, but also neuronal in nature. In the non-obese diabetic (NOD) mouse model of T1D, a mutant sensory neuron channel, TRPV1, initiates chronic, progressive β-cell stress, inducing islet cell inflammation. This novel mechanism of organ-specific damage requires a...
Paper Details
Title
‘Sensing’ autoimmunity in type 1 diabetes
Published Date
Oct 1, 2007
Journal
Volume
13
Issue
10
Pages
405 - 413
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