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Effects of haw pectic oligosaccharide on lipid metabolism and oxidative stress in experimental hyperlipidemia mice induced by high-fat diet

Published on Aug 1, 2010in Food Chemistry5.40
· DOI :10.1016/j.foodchem.2010.01.039
Tuoping Li9
Estimated H-index: 9
(Liaoning University),
Suhong Li7
Estimated H-index: 7
(SYNU: Shenyang Normal University)
+ 5 AuthorsHuili Zhang1
Estimated H-index: 1
(Liaoning University)
Abstract
The anti-hyperlipidemic and antioxidant effects of haw pectic oligosaccharide (HPOS) were investigated using a model of hyperlipidemia induced by a high-fat diet in mice. HPOS significantly lowered the serum levels of total cholesterol (p < 0.01) and triglycerides (p < 0.05) and inhibited the accumulation of body fat in this model. It significantly enhanced the activity of superoxide dismutase to suppress oxidative reactions (p < 0.01) and inhibited the synthesis and accumulation of malondialdehyde in serum (p < 0.05). Thus, HPOS could be valuable in the development of nutritional and drug therapies to combat cardiovascular diseases.
  • References (16)
  • Citations (35)
References16
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#1Mika J. Thomson (St George's, University of London)H-Index: 2
#2Valentina O. Puntmann (St George's, University of London)H-Index: 22
Last.Juan Carlos Kaski (St George's, University of London)H-Index: 68
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#1Fanny Robbesyn (French Institute of Health and Medical Research)H-Index: 5
#2Robert Salvayre (French Institute of Health and Medical Research)H-Index: 56
Last.Anne Nègre-Salvayre (French Institute of Health and Medical Research)H-Index: 50
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#2Bikash Kumar (Central University of Rajasthan)H-Index: 1
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#1Dongmei Wu (ZJU: Zhejiang University)
#2Jiaqi Zheng (ZJU: Zhejiang University)
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#1Qingbin Guo (U of G: University of Guelph)H-Index: 15
#2Jinhua Du (SDAU: Shandong Agricultural University)H-Index: 1
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#1Lulu Chu (JXAU: Jiangxi Agricultural University)
#2Licong Yang (JXAU: Jiangxi Agricultural University)H-Index: 2
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#1Huajie Zhao (SDAU: Shandong Agricultural University)H-Index: 9
#2Jianjun Zhang (SDAU: Shandong Agricultural University)H-Index: 16
Last.Le Jia (SDAU: Shandong Agricultural University)H-Index: 18
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#1Zhenzhen Ren (SDAU: Shandong Agricultural University)H-Index: 7
#2Juan LiH-Index: 5
Last.Le Jia (SDAU: Shandong Agricultural University)H-Index: 18
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#1Chao Zhao (Fujian Agriculture and Forestry University)H-Index: 5
#2Yijing Wu (Fujian Agriculture and Forestry University)H-Index: 1
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