Effects of haw pectic oligosaccharide on lipid metabolism and oxidative stress in experimental hyperlipidemia mice induced by high-fat diet

Published on Aug 1, 2010in Food Chemistry5.399
· DOI :10.1016/j.foodchem.2010.01.039
Tuoping Li9
Estimated H-index: 9
(Liaoning University),
Suhong Li10
Estimated H-index: 10
(SYNU: Shenyang Normal University)
+ 5 AuthorsHuili Zhang1
Estimated H-index: 1
(Liaoning University)
The anti-hyperlipidemic and antioxidant effects of haw pectic oligosaccharide (HPOS) were investigated using a model of hyperlipidemia induced by a high-fat diet in mice. HPOS significantly lowered the serum levels of total cholesterol (p < 0.01) and triglycerides (p < 0.05) and inhibited the accumulation of body fat in this model. It significantly enhanced the activity of superoxide dismutase to suppress oxidative reactions (p < 0.01) and inhibited the synthesis and accumulation of malondialdehyde in serum (p < 0.05). Thus, HPOS could be valuable in the development of nutritional and drug therapies to combat cardiovascular diseases.
  • References (16)
  • Citations (37)
📖 Papers frequently viewed together
11 Citations
440 Citations
251 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Zhong Hui (Tianjin Agricultural University)H-Index: 1
Although pectin is believed to play an important role as food thickening agent,its role as an antioxidant was rarely reported.In this study,four -fraction hydrolyzates of haw pectin were prepared by enzymolysis and ultra -filtration,and their antioxidant activities were investigated.All those hydrolyzates showed dose-dependent scavenging activities for superoxide anions(O2-·),hydroxyl radicals(·OH) and DPPH radicals(DPPH·),with the scavenging rates approximately 100 % for all the three radicals ...
5 Citations
#1LI Tuo-ping (Tianjin University of Science and Technology)H-Index: 1
The production conditions of oligosaccharides including enzymolysis time, substrate concentration and dose of enzyme (Rapidase and pectase powder), which will affect the degradation efficiency of haw pectin and dynamic production of oligosaccharides, were investigated in this work. The result showed that reducing sugar of pectin solution treated by two kind of pectinase increased rapidly in the beginning 4 h, and after that went smoothly. The average degree of polymerization of oligosaccharides ...
6 Citations
The nature of carbohydrate is of considerable importance when recommending diets intended to reduce the risk of type II diabetes and cardiovascular disease and in the treatment of patients who already have established diseases. Intact fruits, vegetables, legumes and wholegrains are the most appropriate sources of carbohydrate. Most are rich in nonstarch polysaccharides (NSPs) (dietary fibre) and other potentially cardioprotective components. Many of these foods, especially those that are high in...
82 CitationsSource
#1Mika J. C. B. Thomson (St George's, University of London)H-Index: 2
#2Valentina O. Puntmann (St George's, University of London)H-Index: 27
Last. Juan-Carlos Kaski (St George's, University of London)H-Index: 15
view all 3 authors...
Extensive experimental data have revealed a central role for oxidative stress in atherogenesis and suggested a potential role for ‘antioxidant’ treatment in cardiovascular disease (CVD) [1–11]. Experimental data, however, have not translated into clinical benefit: most antioxidant vitamin trials have failed to reduce cardiovascular morbidity and mortality [12]. Moreover, recent clinical trials have suggested that mono-therapy with certain antioxidant vitamins like vitamin E may, in fact, be detr...
77 CitationsSource
#1Milan Marounek (CAS: Academy of Sciences of the Czech Republic)H-Index: 23
#2Zdeněk VolekH-Index: 6
Last. Jana ČopíkováH-Index: 16
view all 4 authors...
Summary Two experiments were performed to compare the effect of pectin and its hydrophobic derivatives on homeostasis of cholesterol and cecal metabolism in male young rats. Control rats were fed a diet supplemented with palm fat and cholesterol (50 and 10 g/kg, respectively). Rats of other groups were fed the same diet containing citrus pectin or octadecylpectinamide (60 g/kg). Diets were fed for 4 weeks. In experiment I, pectinamide of lower degree of amidation (30 %) increased serum HDL chole...
52 Citations
#1Antonio Cherubini (University of Perugia)H-Index: 68
Last. Renato FellinH-Index: 37
view all 6 authors...
Low density lipoprotein (LDL) oxidative modification in the vascular wall seems to be a key factor in atherosclerosis development. Oxidised LDLs might recruit monocytes and favour their transformation into foam cells through a receptor-mediated intake (scavenger pathway). Moreover oxidised LDLs show cytotoxic potential which is probably responsible for endothelial cell damage and macrophage degeneration in the atherosclerotic human plaque. Following the oxidation hypothesis of atherosclerosis th...
97 CitationsSource
#1Fanny Robbesyn (French Institute of Health and Medical Research)H-Index: 8
#1Fanny Robbesyn (French Institute of Health and Medical Research)H-Index: 5
Last. Anne Nègre-Salvayre (French Institute of Health and Medical Research)H-Index: 56
view all 3 authors...
Atherosclerosis is a slowly evolutive age-linked disease of large arteries, characterized by a local lipid deposition associated with a chronic inflammatory response, leading potentially to acute plaque rupture, thrombosis and ischemic heart disease. Atherogenesis is a complex sequence of events associating first expression of adhesion molecules, recruitment of mononuclear cells to the endothelium, local activation of leukocytes and inflammation, lipid accumulation and foam cell formation. Low d...
118 CitationsSource
Abstract Overproduction of reactive oxygen species or increased oxidative stress is considered a major mechanism involved in the pathogenesis of endothelial dysfunction, the initiation and progression of atherosclerosis and its adverse events. Evidence supports the importance of nitric oxide derived from endothelial nitric oxide synthase as a vasoprotective substance, and of vascular NAD(P)H oxidase-derived reactive oxygen species as important signaling molecules in vascular cells. Recent studie...
57 CitationsSource
ミカンの搾汁残渣中に含まれるペクチン酸は鉛 (II) イオンと強力に錯形成する性質を有する。この性質を利用して, 搾汁直後の湿潤状態の残渣に水酸化カルシウムを添加し, 粉砕することにより加水分解処理を行い, ペクチン酸の含有量を高めたものを鉛の吸着剤として使用した。水溶液中の鉛イオンの吸着・除去に及ぼす水酸化カルシウムの添加量, 吸着剤の乾燥重量と水溶液体積との比率, 接触時間, ならびに水溶液のpHの影響について調べた。湿潤状態の残渣には腐敗の問題があり, 長期間にわたる使用には問題がある。そこで現在家畜飼料として市販されているロータリーキルンを用いて高温乾燥処理した搾汁残渣との吸着・除去性能の比較を行った。その結果以下のことが明らかとなった。(1) 上記の処理をした湿潤状態の搾汁残渣ではpHが4~7の広範なpH領域においてほぼ100%の鉛の除去が達成された。(2) しかし水溶液のpHが8以上の場合や, 添加する水酸化カルシウムの割合が大きすぎる場合には鉛の除去は大きく低下した。(3) 高温乾燥処理した搾汁残渣では上記の処理をした湿潤状態のものと比較すると, 特に固-液比が小さい場合...
4 CitationsSource
#1Hiroaki Masuzaki (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 4
#1Hiroaki MasuzakiH-Index: 51
Last. Jeffrey S. FlierH-Index: 121
view all 7 authors...
The adverse metabolic consequences of obesity are best predicted by the quantity of visceral fat. Excess glucocorticoids produce visceral obesity and diabetes, but circulating glucocorticoid levels are normal in typical obesity. Glucocorticoids can be produced locally from inactive 11-keto forms through the enzyme 11β hydroxysteroid dehydrogenase type 1 (11β HSD-1). We created transgenic mice overexpressing 11β HSD-1 selectively in adipose tissue to an extent similar to that found in adipose tis...
1,539 CitationsSource
Cited By37
#1Catarina Moreirinha (University of Aveiro)H-Index: 9
#2Carla Vilela (University of Aveiro)H-Index: 19
Last. Carmen S.R. Freire (University of Aveiro)H-Index: 46
view all 10 authors...
Abstract In this study, brewers' spent grain (BSG) arabinoxylans-based nanocomposite films were prepared by solvent casting of arabinoxylans (AX) suspensions containing different amounts of nanofibrillated cellulose (NFC, 5, 10, 25, 50 and 75% mass fraction). The obtained nanocomposite films were homogeneous and presented thermal stability up to 230 °C and good mechanical properties (Young's modulus up to 7.5 GPa). Additionally, the films with 50% NFC were loaded with ferulic acid or feruloylate...
1 CitationsSource
#1Minghui Liu (Sichuan Agricultural University)
#2Xiangbing MaoH-Index: 19
Last. Jianping WangH-Index: 11
view all 12 authors...
Abstract As a kind of green additives, pectic oligosaccharide (POS) may regulate some physiological functions, such as gut health, antioxidant capacity, immunity and lipid metabolism. This study aimed to identify whether POS administration improved maternal reproduction, and the possible metabolism was also determined. A total of 48 pregnant Wistar rats were randomly allotted into 1 of 2 groups and were fed the diets supplemented 0 or 800 mg/kg POS. POS administration increased piglet and rat bo...
#1Xinman Lou (NWAFU: Northwest A&F University)H-Index: 1
#2Bo Yuan (NU: University of Nebraska–Lincoln)H-Index: 6
Last. Long YuanH-Index: 1
view all 6 authors...
Hawthorn berry (Crataegus pinnatifida), approved as ‘medicine food homology’ fruit by China’s National Health Commission, has been associated with positive effects on human health. In‐depth study of nutritional composition and antioxidant capacity can provide basic information on food value of Chinese organic frozen (OFHB)/freeze‐dried (OFDHB) hawthorn berries. Higher levels of dietary fibre, pectin, ascorbic acid, mineral and antioxidant capacity were found compared with some common fruits and ...
3 CitationsSource
#1Min WuH-Index: 2
#2Longtao LiuH-Index: 2
Last. Yu CaoH-Index: 3
view all 6 authors...
Cardiovascular disease (CVD), especially atherosclerosis, is a leading cause of morbidity and mortality globally; it causes a considerable burden on families, and caregivers, and results in significant financial costs being incurred. Hawthorn has an extensive history of medical use in many countries. In China, the use of hawthorn for the treatment of cardiovascular disease dates to 659 AD. In addition, according to the theory of traditional Chinese medicine, it acts on tonifying the spleen to pr...
2 CitationsSource
#1Sanusi Bello Mada (ABU: Ahmadu Bello University)H-Index: 8
#2M. M. Abarshi (ABU: Ahmadu Bello University)H-Index: 2
Last. I. Garba (Uthman dan Fodiyo University)H-Index: 1
view all 9 authors...
#1Fernanda Aline de Moura (UFSM: Universidade Federal de Santa Maria)H-Index: 3
#2Fernanda Teixeira Macagnan (UFSM: Universidade Federal de Santa Maria)H-Index: 4
Last. Leila Picolli da Silva (UFSM: Universidade Federal de Santa Maria)H-Index: 15
view all 4 authors...
Abstract Hydrolysis of polysaccharides produces low molecular weight carbohydrates with singular physicochemical characteristics, depending on the source of polysaccharide and on the hydrolysis process. The aim of this study was to partially hydrolyze the pectin obtained from passion fruit peel and to determine its molar mass and physicochemical properties. 0.25N HCl at 60 °C for 2, 3 or 4 h was used for the hydrolysis. Molar mass, uronic acid content, water holding capacity, fat absorption capa...
#1Nisha Bhardwaj (Central University of Rajasthan)H-Index: 6
#2Bikash Kumar (Central University of Rajasthan)H-Index: 6
Last. Pradeep Verma (Central University of Rajasthan)H-Index: 10
view all 3 authors...
Xylan is the second most abundant naturally occurring renewable polysaccharide available on earth. It is a complex heteropolysaccharide consisting of different monosaccharides such as l-arabinose, d-galactose, d-mannoses and organic acids such as acetic acid, ferulic acid, glucuronic acid interwoven together with help of glycosidic and ester bonds. The breakdown of xylan is restricted due to its heterogeneous nature and it can be overcome by xylanases which are capable of cleaving the heterogene...
6 CitationsSource
#1Dongmei Wu (ZJU: Zhejiang University)H-Index: 3
#2Jiaqi Zheng (ZJU: Zhejiang University)H-Index: 3
Last. Shiguo Chen (ZJU: Zhejiang University)H-Index: 28
view all 7 authors...
AbstractRhamnogalacturonan I (RG-I) pectin is composed of backbone of repeating disaccharide units →2)-α-L-Rhap-(1→4)-α-D-GalpA-(1→ and neutral sugar side-chains mainly consisting of arabinose and ...
7 CitationsSource
#1Qingbin Guo (U of G: University of Guelph)H-Index: 17
#2Jinhua Du (SDAU: Shandong Agricultural University)H-Index: 1
Last. Steve W. Cui (AAFC: Agriculture and Agri-Food Canada)H-Index: 44
view all 5 authors...
Abstract The fruit of hawthorn (Crataegus pinnatifida Bge. var. major) is rich in pectic polysaccharides and has been used for centuries in China as food and herb. Hawthorn pectin (HP) recently has attracted rising attention due to the reported functional properties (e.g. gelling, emulsification) and health benefits towards the cardiovascular system. In this study, using hawthorn wine residue as raw material, a high methoxylated pectic polysaccharide HSP (degree of esterification up to 70%) was ...
11 CitationsSource