Effects of haw pectic oligosaccharide on lipid metabolism and oxidative stress in experimental hyperlipidemia mice induced by high-fat diet

Published on Aug 1, 2010in Food Chemistry5.40
· DOI :10.1016/j.foodchem.2010.01.039
Tuoping Li9
Estimated H-index: 9
(Liaoning University),
Suhong Li7
Estimated H-index: 7
(SYNU: Shenyang Normal University)
+ 5 AuthorsHuili Zhang1
Estimated H-index: 1
(Liaoning University)
The anti-hyperlipidemic and antioxidant effects of haw pectic oligosaccharide (HPOS) were investigated using a model of hyperlipidemia induced by a high-fat diet in mice. HPOS significantly lowered the serum levels of total cholesterol (p < 0.01) and triglycerides (p < 0.05) and inhibited the accumulation of body fat in this model. It significantly enhanced the activity of superoxide dismutase to suppress oxidative reactions (p < 0.01) and inhibited the synthesis and accumulation of malondialdehyde in serum (p < 0.05). Thus, HPOS could be valuable in the development of nutritional and drug therapies to combat cardiovascular diseases.
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  • Citations (35)
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