Boric acid single dose pharmacokinetics after intravenous administration to man

Eight young adult male volunteers with a basic (alimentary) plasma boric acid concentration of less than 0.10 - 0.46 mg/l were given a single dose of boric acid (562-611 mg) by 20 min IV infusion. The plasma concentration curves, followed for 3 days, best fitted a three-compartment open model, although two subjects had to be left out due to inconstant basal plasma concentration values or failure to fit to the three-compartment model. The 120 h...