Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations

Hyperuricemia is associated with multiple diseases, including gout, cardiovascular disease, and renal disease. Serum urate is highly heritable, yet association studies of single nucleotide polymorphisms (SNPs) and serum uric acid explain a small fraction of the heritability. Whether copy number polymorphisms (CNPs) contribute to uric acid levels is unknown.We assessed copy number on a genome-wide scale among 8,411 individuals of European...