EVIDENCE OF AN EICOSANOID CONTRIBUTION TO IL-1 INDUCTION OF IL-6 IN HUMAN ARTICULAR CHONDROCYTES
Abstract
It has been demonstrated previously that interleukin-1 (IL-1) induces articular cartilage explants and chondrocytes in culture to produce elevated levels of inflammatory mediators such as interleukin-6 (IL-6) and prostaglandins. Previous studies have also demonstrated a relationship between IL-6 secretion and the ability of IL-1 to modulate proteoglycan synthesis by chondrocytes. In this study we have utilized an alginate culture system in an...
Paper Details
Title
EVIDENCE OF AN EICOSANOID CONTRIBUTION TO IL-1 INDUCTION OF IL-6 IN HUMAN ARTICULAR CHONDROCYTES
Published Date
Feb 1, 1996
Volume
3
Issue
2
Pages
101 - 108
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