MP-15.08: Detection of TMPRSS2–ERG Fusion Gene in Urine and Blood of Prostate Cancer Patients

Since prostate cells can be detected in the urine and in blood of men with prostate cancer, urine or blood based diagnostic tests have been tested using prostate cancer cell specific markers. Reports in the last years have shown that PCa frequently over-express the ETS family members ETV1 and ERG and that as many as 70% of such PCa have chromosomal rearrangements that lead to the fusion of the 5' end of the androgen regulated serine protease...