1 – Introduction to biomaterials and implantable device design

Published on Jan 1, 2014
· DOI :10.1533/9781782422662.1
Elena P. Ivanova3
Estimated H-index: 3
Kateryna Bazaka26
Estimated H-index: 26
Russell J. Crawford3
Estimated H-index: 3
: Replacement and regeneration of lost function or tissue with well-matched biomaterials remains an area of active research and development, driving demand for novel and improved biomaterials. The ever-increasing complexity and high degree of integration of additives in modern biomaterials have significantly expanded the scope of biomaterial applications, but this has also introduced novel challenges. In this chapter, implantable electronic devices are used to demonstrate key issues and challenges associated with the design of complex implantable systems.
  • References (137)
  • Citations (3)
📖 Papers frequently viewed together
17 Citations
1 Author (王振▲軍▼)
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Fernanda C. P. F. Sales (UFABC: Universidade Federal do ABC)H-Index: 4
#2Rodrigo M. Iost (USP: University of São Paulo)H-Index: 11
Last. Frank N. Crespilho (USP: University of São Paulo)H-Index: 23
view all 5 authors...
An intravenous implantable glucose/dioxygen hybrid enzyme–Pt micro-biofuel cell (BFC) was investigated. In this miniaturized BFC, a flexible carbon fiber (FCF) microelectrode modified with neutral red redox mediator and glucose oxidase was used as the bioanode, and an FCF modified with platinum nanoparticles stabilized on PAMAM-G4 dendrimer was used as the cathode. In vitro experiments conducted using the BFC in a phosphate buffer solution (50 mmol L−1, pH = 7.2) and glucose (47 mmol L−1) showed...
65 CitationsSource
#1Serge BovedaH-Index: 24
#2Stéphane GarrigueH-Index: 45
Last. Philippe RitterH-Index: 39
view all 3 authors...
Cardiac pacing has hugely and rapidly improved in just over 50 years, thanks to advances in electronics, computing, nanotechnology, and medicine. Engineers and physicians are committed to reproducing, as closely as possible, the physiological cardiac cycle and the mechanical activity of the right and left ventricles. The history of the implantable cardioverter defibrillator (ICD) is unique because it relies on the bold project of one man, Mirowski. In 1985, the first implantable cardioverter def...
5 CitationsSource
#1Chin Fhong Soon (University of Bradford)H-Index: 7
#2Mansour Youseffi (University of Bradford)H-Index: 14
Last. M. Denyer (University of Bradford)H-Index: 10
view all 5 authors...
Abstract Keratinocyte traction forces play a crucial role in wound healing. The aim of this study was to develop a novel cell traction force (CTF) transducer system based on cholesteryl ester liquid crystals (LC). Keratinocytes cultured on LC induced linear and isolated deformation lines in the LC surface. As suggested by the fluorescence staining, the deformation lines appeared to correlate with the forces generated by the contraction of circumferential actin filaments which were transmitted to...
21 CitationsSource
#1Ja Hoon Koo (Yonsei University)H-Index: 16
#2Jungmok Seo (Yonsei University)H-Index: 20
Last. Taeyoon Lee (Yonsei University)H-Index: 24
view all 3 authors...
Recent efforts in the semiconductor industry have focused on the realization of electronics with unusual form factors and functions which are not achievable using the current planar Si-based technology. Deposition of high-quality films or nanomaterials on low-temperature elastomeric substrates has been a technical challenge for flexible electronics. However, together with the development of new synthesis routes that enable the formation of robust thin films and nanomaterials on compliant substra...
22 CitationsSource
#1Patrick P. MercierH-Index: 22
#2Andrew C. LysaghtH-Index: 8
Last. Konstantina M. StankovicH-Index: 22
view all 5 authors...
The energy of the electrochemical potential in the guinea pig cochlea is harvested and used to power a wireless transmitter.
119 CitationsSource
#1Bruno Guerci (French Institute of Health and Medical Research)H-Index: 35
#2C. Bourgeois (French Institute of Health and Medical Research)H-Index: 2
Last. P. Böhme (French Institute of Health and Medical Research)H-Index: 1
view all 5 authors...
Abstract Diabetic gastroparesis is a component of autonomic neuropathy, and is the most common manifestation of gastrointestinal neuropathy. Diabetes is responsible for about one quarter of gastroparesis. The upper gastrointestinal symptoms are often non-specific and dominated by nausea, vomiting, early satiety, fullness, bloating. We also have to look for diabetic gastroparesis in case of metabolic instability, such as postprandial hypoglycaemia. The pathophysiology of diabetic gastroparesis is...
17 CitationsSource
#1Marie M Bismark (University of Melbourne)H-Index: 16
#2Andrew J. Gogos (Royal Melbourne Hospital)H-Index: 9
Last. David M. Studdert (University of Melbourne)H-Index: 47
view all 6 authors...
Summary Background Plastic surgeons and other doctors who perform cosmetic procedures face relatively high risks of malpractice claims and complaints. In particular, alleged problems with the consent process abound in this area, but little is known about the clinical circumstances of these cases. Method We reviewed 481 malpractice claims and serious health care complaints resolved in Australia between 2002 and 2008 that alleged failures in the informed consent process for cosmetic and other proc...
17 CitationsSource
#1Erin E. Leary Pararas (Charles Stark Draper Laboratory)H-Index: 5
#2David A. Borkholder (RIT: Rochester Institute of Technology)H-Index: 15
Last. Jeffrey T. Borenstein (Charles Stark Draper Laboratory)H-Index: 40
view all 3 authors...
The inner ear represents one of the most technologically challenging targets for local drug delivery, but its clinical significance is rapidly increasing. The prevalence of sensorineural hearing loss and other auditory diseases, along with balance disorders and tinnitus, has spurred broad efforts to develop therapeutic compounds and regenerative approaches to treat these conditions, necessitating advances in systems capable of targeted and sustained drug delivery. The delicate nature of hearing ...
43 CitationsSource
#2John T. SantiniH-Index: 1
Last. Robert Langer (MIT: Massachusetts Institute of Technology)H-Index: 229
view all 3 authors...
This review covers reservoir-based drug delivery systems that incorporate microtechnology, with an emphasis on oral, dermal, and implantable systems. Key features of each technology are highlighted such as working principles, fabrication methods, dimensional constraints, and performance criteria. Reservoir-based systems include a subset of microfabricated drug delivery systems and provide unique advantages. Reservoirs, whether external to the body or implanted, provide a well-controlled environm...
105 CitationsSource
#1Hariharasudhan D. Chirra (UCSF: University of California, San Francisco)H-Index: 7
#2Tejal A. Desai (UCSF: University of California, San Francisco)H-Index: 62
The development of oral drug delivery platforms for administering therapeutics in a safe and effective manner across the gastrointestinal epithelium is of much importance. A variety of delivery systems such as enterically coated tablets, capsules, particles, and liposomes have been developed to improve oral bioavailability of drugs. However, orally administered drugs suffer from poor localization and therapeutic efficacy due to various physiological conditions such as low pH, and high shear inte...
31 CitationsSource
Cited By3
#1Kordian Chamerski (JDU: Jan Długosz University)H-Index: 2
#2Witold KorzekwaH-Index: 2
Last. Maciej Sitarz (AGH University of Science and Technology)H-Index: 23
view all 7 authors...
One of the most important field of interest in respect to hydrogel materials is their capability to water storage. The problem mentioned above plays an important role regarding to diffusion of fluid media containing nanoparticles, what is very useful in biomedical applications, such as artificial polymeric implants, drug delivery systems or tissue engineering.
1 CitationsSource
#1X.H. Sun (Tianjin Normal University)H-Index: 2
#2Yupeng Pan (Tianjin Normal University)H-Index: 3
Last. D.J. Li (Tianjin Normal University)H-Index: 3
view all 7 authors...
Abstract Ag/TiN-Ag composite multilayers were deposited on Si and Ti-6Al-4V substrates using a multi-target magnetron co-sputtering system. X-ray diffraction (XRD) and transmission electron microscopy (TEM) indicated that the Ag/TiN-Ag composite multilayers exhibited a weaker TiN textures with the smaller modulation period (Λ), which proved the smaller Λ can block the growth of columnar grain and particle, inducing a smoother surface and smaller roughness parameters (R a : 0.82 nm; R q : 1.2 nm)...
3 CitationsSource
#1Xiuhua Sun (Tianjin Normal University)H-Index: 1
#2Huanhuan Gong (Tianjin Normal University)H-Index: 3
Last. Hanqing Gu (Tianjin Medical University)H-Index: 4
view all 7 authors...
2 CitationsSource