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Treatment of brittle fingernails and onychoschizia with biotin: Scanning electron microscopy

Published on Dec 1, 1990in Journal of The American Academy of Dermatology7.102
· DOI :10.1016/0190-9622(90)70345-I
Victor E. Colombo2
Estimated H-index: 2
,
Francoise Gerber2
Estimated H-index: 2
+ 1 AuthorsGeorge L. Floersheim1
Estimated H-index: 1
Sources
Abstract
Pathologic hoof changes in horses and swine can be normalized by administration of biotin. This vitamin had been given orally to women with brittle fingernails or onychoschizia. The aim of the study was to test whether the favorable clinical results could be corroborated by scanning electron microscopy. We investigated the distal ends of the fingernails from 32 persons. They were placed into three groups: group A consisted of 10 control subjects with normal nails, group B comprised eight patients with brittle nails studied before and after biotin treatment, and group C was 14 patients with brittle nails in whom the administration of biotin did not coincide exactly with the initial and terminal clipping of the nails. The thickness of the nails in group B increased significantly by 25%. In group C, the increase was 7%. Splitting of the nails were reduced in groups B and C and the irregular cellular arrangement of the dorsal surface of brittle nails became more regular in all nails of group B and in 8 of 11 nails of group C.
  • References (24)
  • Citations (74)
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References24
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#1Hans Geyer (UZH: University of Zurich)H-Index: 12
#2J. Pohlenz (UZH: University of Zurich)H-Index: 3
Last. L. Völker (Hoffmann-La Roche)H-Index: 3
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Zusammenfassung An je 6 Veredelte Landschweine wurde ab dem Alter von 4 Wochen eine Biotinmangeldiat bzw. eine biotinhaltige Kontrolldiat verabreicht. Die Mangeltiere zeigten die starksten Veranderungen nach 8–10 Wochen Versuchsdauer. Dabei waren der Haarausfall, die Pustelbildung an der Haut und die Bildung eines minderwertigen, brockligen und krustosen Hornes in umschriebenen Bezirken der dorsalen und seitlichen Klauenteile die wichtigsten klinischen Befunde. Die mikroskopische Untersuchung de...
8 CitationsSource
#1H. R. Glättli (Hoffmann-La Roche)H-Index: 1
#2J. Pohlenz (Hoffmann-La Roche)H-Index: 1
Last. F. Ehrensperger (Hoffmann-La Roche)H-Index: 1
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Zusammenfassung In vier Versuchen mit SPF-Ferkeln im Alter von 10–31 Tagen bei Versuchsbeginn wurden durch Zulagen von Avidin in Form von Eiklarpulver Biotinmangelsymptome erzeugt. Diese manifestierten sich in mangelnder Gewichtszunahme, Verlust des Haarglanzes, Schuppung der Haut, Pusteln und Borkenbildung in der Epidermis. Ferner wurden regelmasig Kronsaum- und/oder Wand- sowie Sohlenlasionen an den Klauen beobachtet. Gleichzeitig traten Schleimhautveranderungen an der Zunge, im Maul und Oesop...
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#1M. Dorn (LMU: Ludwig Maximilian University of Munich)H-Index: 1
#2H. H. Wolff (LMU: Ludwig Maximilian University of Munich)H-Index: 1
Zusammenfassung Onychomykotische Fingernagel werden lichtmikroskopisch im Hellfeld und im Inter-ferenzkontrast-Verfahren, sowie rasterelektronenmikroskopisch untersucht. Die Morphologie der Dermatophyteninvasion in die Nagelplatte bei distaler subungualer Onychomykose wird dargestellt. Im Interferenzkontrastverfahren wird das zunachst interzellulare Wachstum der Pilze gezeigt. In der dreidimensionalen Darstellung des Rasterelektronenmikroskops findet sich dagegen herdformiges Eindringen der Hyph...
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• The important role of biotin in human physiology has been highlighted by the recognition of two newly discovered human inborn errors of the metabolism of biotin. The molecular defect in the neonatal-onset disease is in the enzyme holocarboxylase synthetase. The defect in the later infantile-onset disease is in the enzyme biotinidase. Both disorders present with impressive clinical manifestations involving the skin and hair. In the neonatal disease, alopecia totalis is associated with a bright ...
42 CitationsSource
Two types of defect were observed when hoof clippings from horses with brittle feet were viewed in the scanning electron microscope. The first defect showed a loss of structure and horn in the stratum externum. This defect was remedied after biotin treatment. The second defect showed poor attachment of the horn squames and failed to respond to biotin treatment alone. An improvement in this case was achieved by the addition of powdered limestone to the diet.
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Only few reports exist about the occurrence of brittle nails. We examined 1,584 persons with respect to the incidence of this anomaly. The patients were from five different groups: outpatients of a de
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Three children are reported with uncombable hair syndrome, consisting of slow-growing, straw-colored scalp hair that could not be combed flat. The hairs appeared normal on light microscopy but on scanning electron microscopy were triangular in cross section, with canal-like longitudinal depressions. Oral biotin, 0.3 mg three times a day, produced significant improvement after 4 months in one patient, with increased growth rate and with strength and combability of the hair, although the triangula...
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#1N CombenH-Index: 1
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Horses with weak hoof horn, which becomes misshapen and crumbles around the lower parts of the hoof walls, pose problems for treatment in practice. The effects of dietary supplementation with a high level of the B-group vitamin biotin (which has proved successful in the treatment of the similar condition in pigs) were investigated in more than 40 cases. Varying degrees of improvement in the hardness, integrity and conformation of the hoof horn were observed in all cases. The signs and progress s...
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Supplementary biotin (1 mg d-biotin/kg feed) increased the compressive strength of the mid-abaxial sidewall region of pig9s hoof from 9.3 (+/- 0.5) X 10(6) N/m2 to 12.0 (+/- 0.5) X 10(6) N/m2 (P less than 0.05). It also increased the hardness of this region, measured on the Shore A and D hardness scales (P less than 0.05). The leading edge of the hoof wall was significantly stronger than the sidewall (P less than 0.001) with a compressive strength of 14.5 (+/- 0.7) X 10(6) N/m2. This site showed...
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