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Treatment of brittle fingernails and onychoschizia with biotin: Scanning electron microscopy

Published on Dec 1, 1990in Journal of The American Academy of Dermatology7.10
· DOI :10.1016/0190-9622(90)70345-I
Victor E. Colombo2
Estimated H-index: 2
,
Françoise Gerber2
Estimated H-index: 2
+ 1 AuthorsGeorge L. Floersheim1
Estimated H-index: 1
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Abstract
Pathologic hoof changes in horses and swine can be normalized by administration of biotin. This vitamin had been given orally to women with brittle fingernails or onychoschizia. The aim of the study was to test whether the favorable clinical results could be corroborated by scanning electron microscopy. We investigated the distal ends of the fingernails from 32 persons. They were placed into three groups: group A consisted of 10 control subjects with normal nails, group B comprised eight patients with brittle nails studied before and after biotin treatment, and group C was 14 patients with brittle nails in whom the administration of biotin did not coincide exactly with the initial and terminal clipping of the nails. The thickness of the nails in group B increased significantly by 25%. In group C, the increase was 7%. Splitting of the nails were reduced in groups B and C and the irregular cellular arrangement of the dorsal surface of brittle nails became more regular in all nails of group B and in 8 of 11 nails of group C.
  • References (23)
  • Citations (70)
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References23
Newest
H. R. Glättli1
Estimated H-index: 1
(Hoffmann-La Roche),
J. Pohlenz1
Estimated H-index: 1
(Hoffmann-La Roche)
+ 1 AuthorsF. Ehrensperger1
Estimated H-index: 1
(Hoffmann-La Roche)
Zusammenfassung In vier Versuchen mit SPF-Ferkeln im Alter von 10–31 Tagen bei Versuchsbeginn wurden durch Zulagen von Avidin in Form von Eiklarpulver Biotinmangelsymptome erzeugt. Diese manifestierten sich in mangelnder Gewichtszunahme, Verlust des Haarglanzes, Schuppung der Haut, Pusteln und Borkenbildung in der Epidermis. Ferner wurden regelmasig Kronsaum- und/oder Wand- sowie Sohlenlasionen an den Klauen beobachtet. Gleichzeitig traten Schleimhautveranderungen an der Zunge, im Maul und Oesop...
Hans Geyer12
Estimated H-index: 12
(UZH: University of Zurich),
J. Pohlenz2
Estimated H-index: 2
(UZH: University of Zurich),
L. Völker3
Estimated H-index: 3
(Hoffmann-La Roche)
Zusammenfassung An je 6 Veredelte Landschweine wurde ab dem Alter von 4 Wochen eine Biotinmangeldiat bzw. eine biotinhaltige Kontrolldiat verabreicht. Die Mangeltiere zeigten die starksten Veranderungen nach 8–10 Wochen Versuchsdauer. Dabei waren der Haarausfall, die Pustelbildung an der Haut und die Bildung eines minderwertigen, brockligen und krustosen Hornes in umschriebenen Bezirken der dorsalen und seitlichen Klauenteile die wichtigsten klinischen Befunde. Die mikroskopische Untersuchung de...
Published on Apr 24, 2009in Mycoses3.06
M. Dorn1
Estimated H-index: 1
(LMU: Ludwig Maximilian University of Munich),
H. H. Wolff1
Estimated H-index: 1
(LMU: Ludwig Maximilian University of Munich)
Zusammenfassung Onychomykotische Fingernagel werden lichtmikroskopisch im Hellfeld und im Inter-ferenzkontrast-Verfahren, sowie rasterelektronenmikroskopisch untersucht. Die Morphologie der Dermatophyteninvasion in die Nagelplatte bei distaler subungualer Onychomykose wird dargestellt. Im Interferenzkontrastverfahren wird das zunachst interzellulare Wachstum der Pilze gezeigt. In der dreidimensionalen Darstellung des Rasterelektronenmikroskops findet sich dagegen herdformiges Eindringen der Hyph...
Published on Dec 1, 1987in Archives of Dermatology
William L. Nyhan1
Estimated H-index: 1
• The important role of biotin in human physiology has been highlighted by the recognition of two newly discovered human inborn errors of the metabolism of biotin. The molecular defect in the neonatal-onset disease is in the enzyme holocarboxylase synthetase. The defect in the later infantile-onset disease is in the enzyme biotinidase. Both disorders present with impressive clinical manifestations involving the skin and hair. In the neonatal disease, alopecia totalis is associated with a bright ...
Published on Jun 13, 1987in Veterinary Record2.10
Sa Kempson1
Estimated H-index: 1
Two types of defect were observed when hoof clippings from horses with brittle feet were viewed in the scanning electron microscope. The first defect showed a loss of structure and horn in the stratum externum. This defect was remedied after biotin treatment. The second defect showed poor attachment of the horn squames and failed to respond to biotin treatment alone. An improvement in this case was achieved by the addition of powdered limestone to the diet.
Published on Jan 1, 1986
D. Lubach1
Estimated H-index: 1
,
R. Wurzinger1
Estimated H-index: 1
Published on Jan 1, 1986in Dermatology2.50
Dietrich Lubach10
Estimated H-index: 10
(Hochschule Hannover),
W. Cohrs1
Estimated H-index: 1
(Hochschule Hannover),
R. Wurzinger1
Estimated H-index: 1
(Hochschule Hannover)
Only few reports exist about the occurrence of brittle nails. We examined 1,584 persons with respect to the incidence of this anomaly. The patients were from five different groups: outpatients of a de
Published on Jul 1, 1985in Journal of The American Academy of Dermatology7.10
Walter B. Shelley11
Estimated H-index: 11
(University of Toledo Medical Center),
E. Dorinda Shelley10
Estimated H-index: 10
(University of Toledo Medical Center)
Three children are reported with uncombable hair syndrome, consisting of slow-growing, straw-colored scalp hair that could not be combed flat. The hairs appeared normal on light microscopy but on scanning electron microscopy were triangular in cross section, with canal-like longitudinal depressions. Oral biotin, 0.3 mg three times a day, produced significant improvement after 4 months in one patient, with increased growth rate and with strength and combability of the hair, although the triangula...
Published on Dec 22, 1984in Veterinary Record2.10
N Comben1
Estimated H-index: 1
,
Rj Clark1
Estimated H-index: 1
,
Dj Sutherland1
Estimated H-index: 1
Horses with weak hoof horn, which becomes misshapen and crumbles around the lower parts of the hoof walls, pose problems for treatment in practice. The effects of dietary supplementation with a high level of the B-group vitamin biotin (which has proved successful in the treatment of the similar condition in pigs) were investigated in more than 40 cases. Varying degrees of improvement in the hardness, integrity and conformation of the hoof horn were observed in all cases. The signs and progress s...
Published on Feb 25, 1984in Veterinary Record2.10
Ng Webb1
Estimated H-index: 1
,
Rh Penny1
Estimated H-index: 1
,
Am Johnston1
Estimated H-index: 1
Supplementary biotin (1 mg d-biotin/kg feed) increased the compressive strength of the mid-abaxial sidewall region of pig9s hoof from 9.3 (+/- 0.5) X 10(6) N/m2 to 12.0 (+/- 0.5) X 10(6) N/m2 (P less than 0.05). It also increased the hardness of this region, measured on the Shore A and D hardness scales (P less than 0.05). The leading edge of the hoof wall was significantly stronger than the sidewall (P less than 0.001) with a compressive strength of 14.5 (+/- 0.7) X 10(6) N/m2. This site showed...
Cited By70
Newest
Published on Mar 1, 2019in Dermatologic Therapy1.74
Hind M. Almohanna , Azhar Ahmed + 1 AuthorsAntonella Tosti52
Estimated H-index: 52
(UM: University of Miami)
People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Micronutrients are major elements in the normal hair follicle cycle, playing a role in cellular turnover, a frequent occurren...
Published on Feb 3, 2019in Journal of Cosmetic Dermatology1.31
Fatma M El-Esawy1
Estimated H-index: 1
(Banha University),
Mohamed Saber Hussein1
Estimated H-index: 1
(Banha University),
Amira I. Mansour3
Estimated H-index: 3
(Banha University)
Published on May 19, 2018in Journal of Dermatological Treatment2.11
Shari R. Lipner6
Estimated H-index: 6
(Cornell University),
Richard K. Scher30
Estimated H-index: 30
(Cornell University)
AbstractAim: To describe the pharmacology, mechanism of action, and clinical reports using biotin to treat nail conditions.Methods: A review of articles indexed for MEDLINE on PubMed using keywords ‘biotin’ and ‘nail’ was performed and applicable articles were selected for review.Results: Clinical trials have shown an improvement in firmness, hardness, and thickness of brittle nails with oral biotin. There are some case reports and series demonstrating that oral biotin may improve triangular wor...
Published on Jan 1, 2018
John Montgomery Yost1
Estimated H-index: 1
(Stanford University)
Many drug classes have been associated with drug-induced nail abnormalities, including antimicrobials, antimalarials, cardiovascular agents, anti-inflammatories, antirheumatics, hormones, neuropsychiatric medications, as well as other agents. The specific nail dystrophies changes that result with each individual agent is determined by the portion of the nail apparatus affected. Photoonycholysis, chromonychia, dyspigmentation of the nail unit, altered growth rate, Beaus’s lines, onychomadesis, pa...
Published on Jan 1, 2018
Nathaniel J. Jellinek14
Estimated H-index: 14
(Brown University),
Adam I. Rubin12
Estimated H-index: 12
(UPenn: University of Pennsylvania)
In many nail diseases, establishing the diagnosis is rarely difficult or time consuming, and yet the treatment protocol is less automatic. In this chapter, we outline high yield nail topics and present treatment guidelines, with high-yield workup suggestions and treatment caveats included to provide the practitioner with an “at-a glance” resource.
Published on Oct 1, 2017in American Journal of Clinical Dermatology3.84
Jordan M. Thompson4
Estimated H-index: 4
(Brown University),
Mehwish A. Mirza1
Estimated H-index: 1
(Quinnipiac University)
+ 2 AuthorsEunyoung Cho49
Estimated H-index: 49
(Brown University)
Alopecia areata (AA) is a common, non-scarring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Given the role of these micronutrients in normal hair follicle development and in immune cell function, a gro...
View next paperBrittle nails : response to daily biotin supplementation