Stagewise, adaptive dose allocation for quantal response dose-response studies
Abstract
A principal design objective of many dose-response studies is to estimate extreme percentiles of a dose-response distribution, e.g., the ED95 dose for a particular drug therapy, as precisely as feasible using the smallest number of experimental subjects possible. Such a design requirement necessitates that allocation of subjects to drug doses be carried out in a stagewise fashion to maximize the information obtained from each subsequent...
Paper Details
Title
Stagewise, adaptive dose allocation for quantal response dose-response studies
Published Date
Mar 1, 1991
Volume
15
Issue
1
Pages
109 - 114
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