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Is measles vaccination a risk factor for inflammatory bowel disease

Published on Apr 1, 1995in The Lancet59.102
· DOI :10.1016/S0140-6736(95)90816-1
N.P Thompson9
Estimated H-index: 9
(Royal Free Hospital),
Roy E. Pounder50
Estimated H-index: 50
(Royal Free Hospital)
+ 1 AuthorsS.M Montgomery1
Estimated H-index: 1
(City University London)
Abstract
Abstract Measles virus may persist in intestinal tissue, particularly that affected by Crohn's disease, and early exposure to measles may be a risk factor for the development of Crohn's disease. Crohn's disease and ulcerative colitis occur in the same families and may share a common aetiology. In view of the rising incidence of inflammatory bowel disease (Crohn's disease and ulcerative colitis), we examined the impact of measles vaccination upon these conditions. Prevalences of Crohn's disease, ulcerative colitis, coeliac disease, and peptic ulceration were determined in 3545 people who had received live measles vaccine in 1964 as part of a measles vaccine trial. A longitudinal birth cohort of 11407 subjects was one unvaccinated comparison cohort, and 2541 partners of those vaccinated was another. Compared with the birth cohort, the relative risk of developing Crohn's disease in the vaccinated group was 3·01 (95% Cl 1·45-6·23) and of developing ulcerative colitis was 2·53 (1·15-5·58). There was no significant difference between these two groups in coeliac disease prevalence. Increased prevalence of inflammatory bowel disease, but not coeliac disease or peptic ulceration, was found in the vaccinated cohort compared with their partners. These findings suggest that measles virus may play a part in the development not only of Crohn's disease but also of ulcerative colitis.
  • References (26)
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References26
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Objective : To determine whether exposure to a measles epidemic in utero or in infancy is a risk factor for the development of Crohn's disease, and to determine whether such an association can be found in individuals with subacute sclerosing panencephalitis (SSPE), a condition in which early infection with measles is known to be of aetiological importance. Methods : A postal questionnaire was sent to 16875 members of two national inflammatory bowel disease patient support groups. A control group...
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Abstract Background/Aims Infectious agents have long been suspected of playing a role in the initiation of Crohn's disease. The objective of this study was to search for likely microbial agents in diseased tissues using immunocytochemical techniques. Methods Intestines and mesenteric lymph node specimens of 21 patients from two French families with a high frequency of Crohn's disease and from Connecticut were studied. The microbial agents searched for included Bacteroides vulgatus, Borrelia burg...
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