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Biomarkers for the lung cancer diagnosis and their advances in proteomics

Published on Sep 30, 2008in Journal of Biochemistry and Molecular Biology2.966
· DOI :10.5483/BMBRep.2008.41.9.615
Hye-Jin Sung5
Estimated H-index: 5
,
Je-Yoel Cho29
Estimated H-index: 29
(KNU: Kyungpook National University)
Abstract
Over a last decade, intense interest has been focused on bio-marker discovery and their clinical uses. This interest is accel-erated by the completion of human genome project and the progress of techniques in proteomics. Especially, cancer bio-marker discovery is eminent in this field due to its anticipated critical role in early diagnosis, therapy guidance, and prognosis monitoring of cancers. Among cancers, lung cancer, one of the top three major cancers, is the one showing the highest mortal-ity because of failure in early diagnosis. Numerous potential DNA biomarkers such as hypermethylations of the promoters and mutations in K-
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