Platelet adhesion signalling and the regulation of thrombus formation
Abstract
Platelets perform a central role in haemostasis and thrombosis. They adhere to subendothelial collagens exposed at sites of blood vessel injury via the glycoprotein (GP) Ib-V-IX receptor complex, GPVI and integrin alpha(2)beta(1). These receptors perform distinct functions in the regulation of cell signalling involving non-receptor tyrosine kinases (e.g. Src, Fyn, Lyn, Syk and Btk), adaptor proteins, phospholipase C and lipid kinases such as...
Paper Details
Title
Platelet adhesion signalling and the regulation of thrombus formation
Published Date
Jul 15, 2004
Journal
Volume
117
Issue
16
Pages
3415 - 3425
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Notes
History