Match!

Silymarin ameliorates fructose induced insulin resistance syndrome by reducing de novo hepatic lipogenesis in the rat.

Published on Mar 1, 2014in European Journal of Pharmacology3.17
· DOI :10.1016/j.ejphar.2014.01.038
Prem Prakash12
Estimated H-index: 12
(Central Drug Research Institute),
Vishal Singh16
Estimated H-index: 16
(Central Drug Research Institute)
+ 4 AuthorsMadhu Dikshit33
Estimated H-index: 33
(Central Drug Research Institute)
Abstract
Abstract High dietary fructose causes insulin resistance syndrome (IRS), primarily due to simultaneous induction of genes involved in glucose, lipid and mitochondrial oxidative metabolism. The present study evaluates effect of a hepatoprotective agent, silymarin (SYM) on fructose-induced metabolic abnormalities in the rat and also assessed the associated thrombotic complications. Wistar rats were kept on high fructose (HFr) diet throughout the 12-week study duration (9 weeks of HFr feeding and subsequently 3 weeks of HFr plus SYM oral administration [once daily]). SYM treatment significantly reduced the HFr diet-induced increase expression of peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α/β, peroxisome proliferator-activated receptor (PPAR)-α, forkhead box protein O1 (FOXO1), sterol regulatory element binding protein (SREBP)-1c, liver X receptor (LXR)-β, fatty acid synthase (FAS) and PPARγ genes in rat liver. SYM also reduced HFr diet mediated increase in plasma triglycerides (TG), non-esterified fatty acids (NEFA), uric acid, malondialdehyde (MDA), total nitrite and pro-inflammatory cytokines (C-reactive protein [CRP], interleukin-6 [IL-6], interferon-gamma [IFN-γ] and tumor necrosis factor [TNF]) levels. Moreover, SYM ameliorated HFr diet induced reduction in glucose utilization and endothelial dysfunction. Additionally, SYM significantly reduced platelet activation (adhesion and aggregation), prolonged ferric chloride-induced blood vessel occlusion time and protected against exacerbated myocardial ischemia reperfusion (MI-RP) injury. SYM treatment prevented HFr induced mRNA expression of hepatic PGC-1α/β and also its target transcription factors which was accompanied with recovery in insulin sensitivity and reduced propensity towards thrombotic complications and aggravated MI-RP injury.
  • References (62)
  • Citations (27)
References62
Newest
#1Vivek Khanna (Central Drug Research Institute)H-Index: 8
#2Manish Jain (Central Drug Research Institute)H-Index: 14
Last.Madhu Dikshit (Central Drug Research Institute)H-Index: 33
view all 9 authors...
#1Prem Prakash (Central Drug Research Institute)H-Index: 12
#2Vivek Khanna (Central Drug Research Institute)H-Index: 8
Last.Madhu Dikshit (Central Drug Research Institute)H-Index: 33
view all 8 authors...
Cited By27
Newest
#1Yan-Meng Lu (ZJU: Zhejiang University)
#2Jiao-Jiao Xie (ZJU: Zhejiang University)
Last.Lanjuan Li (ZJU: Zhejiang University)H-Index: 48
view all 6 authors...
#1Eva Gatineau (INRA: Institut national de la recherche agronomique)H-Index: 3
#2Frédéric Capel (INRA: Institut national de la recherche agronomique)H-Index: 13
Last.Laurent Mosoni (INRA: Institut national de la recherche agronomique)H-Index: 26
view all 7 authors...
#1Rafiat A. Ajala‐Lawal (College of Health Sciences, Bahrain)H-Index: 2
#2Najeeb O. Aliyu (College of Health Sciences, Bahrain)H-Index: 2
Last.T.O. Ajiboye (College of Health Sciences, Bahrain)H-Index: 4
view all 3 authors...
#1Maryam Vahabzadeh (MUMS: Mashhad University of Medical Sciences)H-Index: 5
#2Nafise Amiri (MUMS: Mashhad University of Medical Sciences)H-Index: 2
Last.Gholamreza Karimi (MUMS: Mashhad University of Medical Sciences)H-Index: 21
view all 3 authors...
#1Babu Nageswararao Kanuri (CSIR: Council of Scientific and Industrial Research)
#2Sanjay C. Rebello (CSIR: Council of Scientific and Industrial Research)
Last.Madhu Dikshit (Indian Institute of Technology, Jodhpur)
view all 10 authors...
View next paper(-)-Epicatechin mitigates high fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress