1-(2-pyrimidinyl)-piperazine, a buspirone metabolite, modulates bladder function in the anesthetized rat

Aims To examine the effects of 1‐(2‐pyrimidinyl)‐piperazine (1‐PP), a buspirone metabolite, on bladder function in vivo. Methods Micturition reflexes in the rat were evaluated in two models of bladder function; a constant infusion model employing 0.5% acetic acid and an isovolumic model. Results In the constant infusion model, 1‐PP (0.14–1.32 mg/kg) dose‐dependently and significantly decreased the number of bladder contractions measured during a...