GnRH Evokes Localized Subplasmalemmal Calcium Signaling in Gonadotropes
Abstract
The binding of GnRH to its receptor initiates signaling cascades in gonadotropes, which result in enhanced LH and FSH biosynthesis and secretion. This process is necessary for follicular maturation and ovulation. Calcium influx activates MAPKs, which lead to increased transcription of LH and FSH genes. Previous research suggests that two MAPK signaling pathways, ERK and jun-N-terminal kinase, are activated by either calcium influx through L-type...
Paper Details
Title
GnRH Evokes Localized Subplasmalemmal Calcium Signaling in Gonadotropes
Published Date
Dec 1, 2014
Journal
Volume
28
Issue
12
Pages
2049 - 2059
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