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Protection Conferred by a Live Avian Metapneumovirus Vaccine when Co-Administered with Live La Sota Newcastle Disease Vaccine in Chicks

Published on Jan 1, 2014in Italian Journal of Animal Science1.26
· DOI :10.4081/ijas.2014.3227
Kannan Ganapathy12
Estimated H-index: 12
(University of Liverpool),
E. Catelli12
Estimated H-index: 12
(UNIBO: University of Bologna)
+ 2 AuthorsR. C. Jones35
Estimated H-index: 35
(University of Liverpool)
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Abstract
This paper examines the effects on specific pathogen-free (SPF) chicks when avian metapneumovirus (aMPV) and Newcastle disease virus (NDV) La Sota strain vaccines are co-administered. Day-old SPF chicks were divided into five groups. The first group was inoculated with sterile water (SW) and the rest of the groups were inoculated with live NDV vaccine VG/GA by the oculo-oral route. At 21 days-old, the unvaccinated chicks were again inoculated with SW. The four VG/GA-vaccinated groups were further inoculated with (i) SW, (ii) live aMPV vaccine, (iii) live NDV La Sota, or (iv) combined live NDV La Sota and live aMPV, respectively. Chicks were monitored for post-vaccination reactions and oropharyngeal swabs were collected for vaccines detection. Blood samples were collected to detect aMPV ELISA and NDV haemagglutination-inhibition antibodies. Twenty-one days following the second vaccination, six chicks from each group were challenged with virulent NDV or aMPV respectively. Chicks were monitored for clinical signs and mortality and oropharyngeal swabs collected for aMPV detection. Results showed that, when challenged with a virulent aMPV, both chicks previously vaccinated with VG/GA and subsequently given aMPV vaccine singly or in combination with La Sota were equally protected against clinical signs. Chicks that were vaccinated against NDV either once with VG/GA or followed by La Sota (singly or in combination with aMPV) were fully protected when challenged with velogenic NDV. We concluded that simultaneous administration of live aMPV and NDV La Sota vaccines have no adverse effects on protection conferred by either live vaccine.
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  • References (26)
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References26
Newest
Published on Dec 1, 2012in Avian Diseases1.31
Mattia Cecchinato12
Estimated H-index: 12
(UNIPD: University of Padua),
Caterina Lupini8
Estimated H-index: 8
(UNIBO: University of Bologna)
+ 4 AuthorsE. Catelli12
Estimated H-index: 12
(UNIBO: University of Bologna)
SUMMARY. The current information on the prevalence of avian metapneumovirus (aMPV) infection in layers is fragmentary and its true impact on egg production often remains unknown or unclear. In order to draw an epidemiologic picture of aMPV presence in layer flocks in Italy, a survey was performed on 19 flocks of pullets and layers based on longitudinal studies or sporadic samplings. aMPV was detected by reverse transcription (RT)-PCR, and blood samples were collected for serology by aMPV ELISA. ...
Published on Jan 1, 2010in Vaccine3.27
E. Catelli12
Estimated H-index: 12
(UNIBO: University of Bologna),
C. Lupini3
Estimated H-index: 3
(UNIBO: University of Bologna)
+ 3 AuthorsC. J. Naylor17
Estimated H-index: 17
(University of Liverpool)
Live avian metapneumovirus (AMPV) vaccines have largely brought turkey rhinotracheitis (TRT) under control in Europe but unexplained outbreaks still occur. Italian AMPV longitudinal farm studies showed that subtype B AMPVs were frequently detected in turkeys some considerable period after subtype B vaccination. Sequencing showed these to be unrelated to the previously applied vaccine. Sequencing of the entire genome of a typical later isolate showed numerous SH and G protein gene differences whe...
Published on Feb 1, 2008in Avian Pathology1.96
Michiel van Boven22
Estimated H-index: 22
(WUR: Wageningen University and Research Centre),
A. Bouma38
Estimated H-index: 38
(UU: Utrecht University)
+ 3 AuthorsG. Koch39
Estimated H-index: 39
(WUR: Wageningen University and Research Centre)
Newcastle disease is an economically important disease of poultry for which vaccination is applied as a preventive measure in many countries. Nevertheless, outbreaks have been reported in vaccinated populations. This suggests that either the vaccination coverage level is too low or that vaccination does not provide perfect immunity, allowing the virus to spread in partially vaccinated populations. Here we study the requirements of an epidemiologically effective vaccination program against Newcas...
Published on Jan 1, 2008
Dennis J. Alexander1
Estimated H-index: 1
,
Richard C. Jones1
Estimated H-index: 1
Published on Sep 1, 2007in Avian Diseases1.31
Kannan Ganapathy12
Estimated H-index: 12
,
R. C. Jones35
Estimated H-index: 35
Abstract Live attenuated subtype B avian metapneumovirus (aMPV) vaccines from two different commercial sources (Vac 1 and Vac 2) were used to vaccinate two groups of day-old specific-pathogen-free chicks. The chicks were challenged at 21 or 49 days of age with a virulent subtype B virus. Parameters compared were persistence of vaccine viruses, their ability to induce humoral antibody responses, and the protection they offered against virulent challenge. Vac 1 virus was detectable for at least 14...
Published on Aug 1, 2007in Avian Pathology1.96
Kannan Ganapathy12
Estimated H-index: 12
(University of Liverpool),
W. J. Cox2
Estimated H-index: 2
(Veterinary Laboratories Agency)
+ 3 AuthorsR. C. Jones35
Estimated H-index: 35
(University of Liverpool)
This paper describes two experiments. In each experiment, 1-day-old specific pathogen free chicks were divided into three groups. In Experiment 1—[avian metapneumo virus (aMPV) challenge]—one group served as unvaccinated controls; the second group was vaccinated with live aMPV (subtype B) vaccine only, and the third group received the aMPV vaccine in combination with live Newcastle disease virus (NDV) vaccine (VG/GA strain). Oropharyngeal swabs, tissues and blood samples were collected before an...
Published on Jun 1, 2007in Avian Diseases1.31
Ian Tarpey2
Estimated H-index: 2
,
M. B. Huggins18
Estimated H-index: 18
,
S. J. Orbell10
Estimated H-index: 10
Abstract Avian metapneumovirus (aMPV), Newcastle disease virus (NDV), and infectious bronchitis virus (IBV) are important respiratory pathogens of chickens. To achieve early posthatch protection against all three diseases it would be helpful to deliver live aMPV, IBV, and NDV vaccines simultaneously at 1 day of age. However, previous work has indicated that the efficacy of aMPV vaccines may be affected when codelivered with IBV or NDV vaccines. The efficacy of an aMPV vaccine when codelivered to...
Published on Feb 1, 2007in Veterinary Immunology and Immunopathology1.85
Martin Liman4
Estimated H-index: 4
,
Silke Rautenschlein20
Estimated H-index: 20
Abstract Most of the studies regarding the immunopathogenesis of avian Metapneumovirus (aMPV) have been done with subtype C of aMPV. Not much is known about the immunopathogenesis of aMPV subtypes A and B in turkeys. Specifically, local immune reactions have not been investigated yet. We conducted two experiments in commercial turkeys. We investigated local and systemic humoral and cell mediated immune reactions following infection with an attenuated vaccine strain of aMPV subtype B (Experiment ...
Published on Dec 1, 2006in Avian Pathology1.96
Kannan Ganapathy12
Estimated H-index: 12
(University of Liverpool),
V. Todd1
Estimated H-index: 1
(University of Liverpool)
+ 2 AuthorsR. C. Jones35
Estimated H-index: 35
(University of Liverpool)
Broiler chicks with maternal antibodies to Newcastle disease virus (NDV) but none to avian metapneumovirus (APV) were divided into six groups. One group was kept as an unvaccinated control group. Three of the other groups were vaccinated at 1 day old with live APV vaccine or one of two live NDV vaccines (VG/GA or HB1). The remaining two groups received the APV vaccine in combination with either of the two NDV vaccines at 1 day old. At intervals after vaccination for up to 42 days, distribution o...
Published on Jan 1, 2006in Journal of Veterinary Medical Science0.91
Miki Sugiyama2
Estimated H-index: 2
(Merial),
Hiroyuki Koimaru1
Estimated H-index: 1
(Merial)
+ 3 AuthorsToshihiro Ito25
Estimated H-index: 25
(Tottori University)
Decreases in egg production and increased incidence of abnormal eggs due to malformation of egg shells were observed in specific pathogen free (SPF) 173-day-old laying hens inoculated intravenously with an avian metapneumovirus (aMPV) strain PLE8T1. This strain was derived from an isolate from broiler birds exhibiting swollen head syndrome (SHS). Some SPF birds inoculated with the virus showed, slight diarrhea without any respiratory symptoms. Thus, the PLE8T1 strain was used as a challenge viru...
Cited By1
Newest
Published on Jul 2, 2016in Italian Journal of Animal Science1.26
Ya-Li Li (ZJU: Zhejiang University), Aikun Fu3
Estimated H-index: 3
(ZJU: Zhejiang University)
+ 2 AuthorsLuo-Qin Fu (ZJU: Zhejiang University)
AbstractPidotimod is a synthetic dipeptide with immunomodulatory activity, but the capacity of pidotimod as an immunologic adjuvant to improve vaccine immunogenicity remains unclear. This study evaluated the effectiveness of pidotimod on immune responses of chickens to Newcastle disease (ND) vaccine, and its efficiency to improve protection against highly virulent ND virus (NDV). A total of 300 one-day-old broilers were divided into five groups (numbered I to V). Group I were unvaccinated and se...
View next paperProtection in specific pathogen free chickens with live avian metapneumovirus and Newcastle disease virus vaccines applied singly or in combination