Tug-of-War in Motor Protein Ensembles Revealed with a Programmable DNA Origami Scaffold

Push Me, Release, Pull You In eukaryotic cells, nearly all long-distance transport of cargos is carried out by the microtubule-based motors kinesin and dynein. These opposite-polarity motors move cargos bidirectionally so that they reach their cellular destinations with spatial and temporal specificity. To understand transport by motor ensembles, Derr et al. (p. 662 , published online 11 October; see the Persective by Diehl ) used a DNA scaffold...