Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism
Abstract
Skeletal muscle is composed of both slow-twitch oxidative myofibers and fast-twitch glycolytic myofibers that differentially impact muscle metabolism, function and eventually whole-body physiology. Here we show that the mesodermal transcription factor T-box 15 (Tbx15) is highly and specifically expressed in glycolytic myofibers. Ablation of Tbx15 in vivo leads to a decrease in muscle size due to a decrease in the number of glycolytic fibres,...
Paper Details
Title
Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism
Published Date
Aug 24, 2015
Journal
Volume
6
Issue
1
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