Emerging strategies in the treatment of advanced hepatocellular carcinoma: the role of targeted therapies

Hepatocellular cancer (HCC) is the fifth most common cause of cancer worldwide and its incidence is increasing as a result of the dissemination of hepatitis B and C virus infection. Surgical resection and liver transplantation are considered the only cures for HCC, but benefit approximately 10–15% of patients. In addition, radiofrequency ablation may is potentially curative for patients’ with small HCC. Some patients with unresectable disease...