Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching

Nature64.80
Volume: 525, Issue: 7567, Pages: 134 - 139
Published: Sep 3, 2015
Abstract
During B-cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same transcriptional orientation as adjacent Cμ constant region exons. In mice, six additional sets of constant region exons (CHs) lie 100-200 kilobases downstream in the same transcriptional orientation as V(D)J and Cμ exons. Long repetitive switch (S)...
Paper Details
Title
Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching
Published Date
Sep 3, 2015
Journal
Volume
525
Issue
7567
Pages
134 - 139
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