Bioavailability of insulin detemir and human insulin at the level of peripheral interstitial fluid in humans, assessed by open‐flow microperfusion

Aims To find an explanation for the lower potency of insulin detemir observed in humans compared with unmodified human insulin by investigating insulin detemir and human insulin concentrations directly at the level of peripheral insulin‐sensitive tissues in humans in vivo . Methods Euglycaemic‐hyperinsulinaemic clamp experiments were performed in healthy volunteers. Human insulin was administered i.v. at 6 pmol/kg/min and insulin detemir at 60...