Match!

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

Published on Nov 1, 2016in British Journal of Clinical Pharmacology3.87
· DOI :10.1111/bcp.12804
Kenneth Maiese1
Estimated H-index: 1
Abstract
Neurodegenerative disorders are significantly increasing in incidence as the age of the global population continues to climb with improved life expectancy. At present, more than 30 million individuals throughout the world are impacted by acute and chronic neurodegenerative disorders with limited treatment strategies. The mechanistic target of rapamycin (mTOR), also known as the mammalian target of rapamycin, is a 289 kDa serine/threonine protein kinase that offers exciting possibilities for novel treatment strategies for a host of neurodegenerative diseases that include Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, stroke and trauma. mTOR governs the programmed cell death pathways of apoptosis and autophagy that can determine neuronal stem cell development, precursor cell differentiation, cell senescence, cell survival and ultimate cell fate. Coupled to the cellular biology of mTOR are a number of considerations for the development of novel treatments involving the fine control of mTOR signalling, tumourigenesis, complexity of the apoptosis and autophagy relationship, functional outcome in the nervous system, and the intimately linked pathways of growth factors, phosphoinositide 3-kinase (PI 3-K), protein kinase B (Akt), AMP activated protein kinase (AMPK), silent mating type information regulation two homologue one (Saccharomyces cerevisiae) (SIRT1) and others. Effective clinical translation of the cellular signalling mechanisms of mTOR offers provocative avenues for new drug development in the nervous system tempered only by the need to elucidate further the intricacies of the mTOR pathway.
  • References (268)
  • Citations (53)
References268
Newest
16 CitationsSource
#1Izabela Krupska (SUNY Downstate Medical Center)H-Index: 1
#2Elspeth A. Bruford (EMBL-EBI: European Bioinformatics Institute)H-Index: 37
Last.Brahim Chaqour (SUNY Downstate Medical Center)H-Index: 21
view all 3 authors...
22 CitationsSource
#1Rikki Hullinger (UW: University of Wisconsin-Madison)H-Index: 8
#2Kenneth J. O'Riordan (Trinity College, Dublin)H-Index: 12
Last.Corinna Burger (UW: University of Wisconsin-Madison)H-Index: 28
view all 3 authors...
28 CitationsSource
#1Jun-Jun SunH-Index: 2
#2Qing-Guo RenH-Index: 6
Last.Zhijun ZhangH-Index: 40
view all 4 authors...
28 CitationsSource
#1Govindasamy-Muralidharan Karthik (KI: Karolinska Institutet)H-Index: 5
#2Ran Ma (KI: Karolinska Institutet)H-Index: 6
Last.Johan Hartman (KI: Karolinska Institutet)H-Index: 23
view all 9 authors...
25 CitationsSource
#1Anatoly B. Uzdensky (SFedU: Southern Federal University)H-Index: 16
#2E. V. Berezhnaya (SFedU: Southern Federal University)H-Index: 6
Last.Svetlana Sharifulina (SFedU: Southern Federal University)H-Index: 4
view all 8 authors...
8 CitationsSource
#1Vijay K. Ramanan (IU: Indiana University)H-Index: 14
#2Kwangsik Nho (IU: Indiana University)H-Index: 32
Last.Andrew J. SaykinH-Index: 90
view all 27 authors...
16 CitationsSource
#1Jintao Wu (SDU: Shandong University)H-Index: 4
#2Dexiao Zhu (SDU: Shandong University)H-Index: 4
Last.Jinhao Sun (SDU: Shandong University)H-Index: 4
view all 6 authors...
17 CitationsSource
14 CitationsSource
#1Rafael Salto (UGR: University of Granada)H-Index: 18
#2Jose D. Vílchez (UGR: University of Granada)H-Index: 5
Last.Jose M. López-PedrosaH-Index: 12
view all 8 authors...
15 CitationsSource
Cited By53
Newest
#1Daisuke Yamada (Okayama University)H-Index: 4
#2Kenji Kawabe (Okayama University)H-Index: 6
Last.Takeshi Takarada (Okayama University)H-Index: 24
view all 15 authors...
Source
#1Zhi Dong Zhou (NUS: National University of Singapore)H-Index: 14
Last.Eng-King Tan (NUS: National University of Singapore)H-Index: 54
view all 5 authors...
2 CitationsSource
#1Laura Caberlotto (University of Trento)H-Index: 25
#2T.-Phuong Nguyen (University of Luxembourg)H-Index: 1
Last.Lucia Carboni (UNIBO: University of Bologna)H-Index: 23
view all 11 authors...
4 CitationsSource
#1Jie Dong (Zhengzhou University)H-Index: 1
#2Hua Li (Zhengzhou University)H-Index: 5
Last.Cong Wu (Zhengzhou University)
view all 4 authors...
Source
#1Pedro Barroso-Chinea (ULL: University of La Laguna)H-Index: 14
#2Diego Luis-Ravelo (ULL: University of La Laguna)H-Index: 2
Last.Tomás González-Hernández (ULL: University of La Laguna)H-Index: 26
view all 13 authors...
Source
#1Huaping Zhang (Shanxi Medical University)H-Index: 3
#2Xiaorong Yang (Shanxi Medical University)
Last.Hui Zhou (Shanxi Medical University)H-Index: 2
view all 6 authors...
Source
#1Hong-Feng Gu (University of South China)H-Index: 9
#2Na Li (University of South China)H-Index: 1
Last.Xin‐Ping OuYang (University of South China)H-Index: 1
view all 9 authors...
1 CitationsSource
#1Ling Xu (DUT: Dalian University of Technology)H-Index: 2
#2Cuili Zhang (Dalian Medical University)H-Index: 1
Last.Yi Xin (Dalian Medical University)H-Index: 1
view all 6 authors...
2 CitationsSource
#1Lei Li (CQMU: Chongqing Medical University)H-Index: 3
#2Jing Xue (SDU: Shandong University)H-Index: 1
Last.Xietong Wang (SDU: Shandong University)H-Index: 7
view all 8 authors...
Source
#1Zuleide M. Ignácio (Sewanee: The University of the South)H-Index: 8
#2João QuevedoH-Index: 2
Last.Gislaine Z. RéusH-Index: 8
view all 3 authors...
Source