Randomized Controlled Trial of CI Therapy for Progressive MS: Increased Real-World Function and Neuroplasticity on MRI (I7-1.008)

OBJECTIVE: null Evaluate Constraint-Induced Movement therapy (CI therapy) for real-world function and neuroplasticity in progressive MS. BACKGROUND: null Progressive MS lacks an established effective treatment. CI therapy has shown efficacy for arm use in stroke and cerebral palsy in clinical trials, but its efficacy for MS is undetermined. However, pilot findings were positive (Mark et al, null Mult Scler null 2008). Therefore, we conducted a...