PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

Volume: 372, Issue: 26, Pages: 2509 - 2520
Published: Jun 24, 2015
Abstract
BackgroundSomatic mutations have the potential to encode “non-self” immunogenic antigens. We hypothesized that tumors with a large number of somatic mutations due to mismatch-repair defects may be susceptible to immune checkpoint blockade. MethodsWe conducted a phase 2 study to evaluate the clinical activity of pembrolizumab, an anti–programmed death 1 immune checkpoint inhibitor, in 41 patients with progressive metastatic carcinoma with or...
Paper Details
Title
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
Published Date
Jun 24, 2015
Volume
372
Issue
26
Pages
2509 - 2520
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