The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation
Abstract
Folate metabolism is central to cell proliferation and a target of commonly used cancer chemotherapeutics. In particular, the mitochondrial folate-coupled metabolism is thought to be important for proliferating cancer cells. The enzyme MTHFD2 in this pathway is highly expressed in human tumors and broadly required for survival of cancer cells. Although the enzymatic activity of the MTHFD2 protein is well understood, little is known about its...
Paper Details
Title
The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation
Published Date
Oct 13, 2015
Journal
Volume
5
Issue
1
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