Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF
Abstract
Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations with rarer variants with larger effects. The aim of this study was to identify low-frequency (minor allele frequency [MAF] ≥0.01 and <0.05) and rare...
Paper Details
Title
Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF
Published Date
Sep 10, 2015
Journal
Volume
126
Issue
11
Pages
e19 - e29
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Notes
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