HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation
Abstract
HIV-1 Nef, a protein important for the development of AIDS, has well-characterized effects on host membrane trafficking and receptor downregulation. By an unidentified mechanism, Nef increases the intrinsic infectivity of HIV-1 virions in a host-cell-dependent manner. Here we identify the host transmembrane protein SERINC5, and to a lesser extent SERINC3, as a potent inhibitor of HIV-1 particle infectivity that is counteracted by Nef. SERINC5...
Paper Details
Title
HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation
Published Date
Sep 30, 2015
Journal
Volume
526
Issue
7572
Pages
212 - 217
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