Effects of Losartan on Blood Pressure, Oxidative Stress, and Nitrate/Nitrite Levels in the Nitric Oxide Deficient Hypertensive Rats
Abstract
Losartan, an angiotensin II type-1 receptor (AT1) antagonist, was used to investigate whether it can offer protection against the sustained hypertension, cardiac hypertrophy, and renal damage induced by chronic inhibition of nitric oxide (NO) by Nω-nitro-L-arginine methyl ester (L-NAME). We studied the involvement of both NO metabolism and oxidative stress in L-NAME-induced hypertension, and how AT1 receptor antagonism may interact. Male Wistar...
Paper Details
Title
Effects of Losartan on Blood Pressure, Oxidative Stress, and Nitrate/Nitrite Levels in the Nitric Oxide Deficient Hypertensive Rats
Published Date
Jan 1, 2004
Journal
Volume
10
Issue
5-6
Pages
147 - 157
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