Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis
Abstract
Secretion of the cytokine interleukin-1β (IL-1β) by macrophages, a major driver of pathogenesis in atherosclerosis, requires two steps: Priming signals promote transcription of immature IL-1β, and then endogenous "danger" signals activate innate immune signaling complexes called inflammasomes to process IL-1β for secretion. Although cholesterol crystals are known to act as danger signals in atherosclerosis, what primes IL-1β transcription...
Paper Details
Title
Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis
Published Date
Jul 17, 2015
Journal
Volume
349
Issue
6245
Pages
316 - 320
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