Diabetes Limits Stem Cell Mobilization Following G-CSF but Not Plerixafor
Abstract
Previous studies suggest that diabetes impairs hematopoietic stem cell (HSC) mobilization in response to granulocyte colony-stimulating factor (G-CSF). In this study, we tested whether the CXCR4 antagonist plerixafor, differently from G-CSF, is effective in mobilizing HSCs in patients with diabetes. In a prospective study, individuals with and without diabetes (n = 10/group) were administered plerixafor to compare CD34+ HSC mobilization;...
Paper Details
Title
Diabetes Limits Stem Cell Mobilization Following G-CSF but Not Plerixafor
Published Date
Mar 24, 2015
Journal
Volume
64
Issue
8
Pages
2969 - 2977
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