Protection against alkylphosphate intoxication by intracerebral injection of 1-methyl-2-for-mylpyridinium iodide oxime (2-PAM).

Prophylactic protection by intraperitoneally administered l-methyl-2-formylpyridinium iodide oxime (2-PAM) against tetraethylpyrophosphate, paraoxon and diisopropyl phosphorofluoridate intoxication in mice was markedly enhanced by intracerebral administration of this antagonist into the central nervous system. Potency ratios and LD50 values of these alkylphosphates were compared in groups of mice premedicated with 2-PAM and/or atropine. The...