Control of ATP concentration inEscherichia coliusing synthetic small regulatory RNAs for enhanced S-adenosylmethionine production

Volume: 362, Issue: 15, Pages: fnv115 - fnv115
Published: Jul 17, 2015
Abstract
ATP is the limiting precursor and driving force for S-adenosylmethionine (SAM) biosynthesis in Escherichia coli. In contrast to traditional optimization of fermentation processes, the synthetic sRNA-based repression strategy, which was developed as a highly efficient gene knockdown approach, has been applied for the regulation of the intracellular ATP concentration in order to enhance SAM production. In this work, proB, glnA and argB, all...
Paper Details
Title
Control of ATP concentration inEscherichia coliusing synthetic small regulatory RNAs for enhanced S-adenosylmethionine production
Published Date
Jul 17, 2015
Volume
362
Issue
15
Pages
fnv115 - fnv115
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