Whole-genome fingerprint of the DNA methylome during human B cell differentiation
Abstract
We analyzed the DNA methylome of ten subpopulations spanning the entire B cell differentiation program by whole-genome bisulfite sequencing and high-density microarrays. We observed that non-CpG methylation disappeared upon B cell commitment, whereas CpG methylation changed extensively during B cell maturation, showing an accumulative pattern and affecting around 30% of all measured CpG sites. Early differentiation stages mainly displayed...
Paper Details
Title
Whole-genome fingerprint of the DNA methylome during human B cell differentiation
Published Date
Jun 8, 2015
Journal
Volume
47
Issue
7
Pages
746 - 756
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