Whole-brain quantitative mapping of metabolites using short echo three-dimensional proton MRSI

Background To improve the extent over which whole brain quantitative three-dimensional (3D) magnetic resonance spectroscopic imaging (MRSI) maps can be obtained and be used to explore brain metabolism in a population of healthy volunteers. Methods Two short echo time (20 ms) acquisitions of 3D echo planar spectroscopic imaging at two orientations, one in the anterior commissure–posterior commissure (AC-PC) plane and the second tilted in the...