Keeping CRISPR/Cas on-Target

Published: Jan 1, 2016
Abstract
CRISPR/Cas, a microbial adaptive immune system, has recently been reshaped as a versatile genome editing approach, endowing genome engineering with high efficiency and robustness. The DNA endonuclease Cas, a component of CRISPR system, is directed to specific target within genomes by guide RNA (gRNA) and performs gene editing function. However, the system is still in its infancy and facing enormous challenges such as off-target mutation. Lots of...
Paper Details
Title
Keeping CRISPR/Cas on-Target
Published Date
Jan 1, 2016
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