Copper, zinc and iron levels in infants and their mothers during the first year of life: a prospective study

Published on Dec 1, 2015in BMC Pediatrics1.983
· DOI :10.1186/s12887-015-0474-9
Tülin Ayse Özden8
Estimated H-index: 8
(Istanbul University),
Gülbin Gökçay12
Estimated H-index: 12
(Istanbul University)
+ 4 AuthorsG. Saner10
Estimated H-index: 10
(Istanbul University)
Essential micronutrients are important for maintenance of life. Deficiency of micronutrients is more likely to be encountered in children, and women studies are required to investigate the status of micronutrients in children and women. This study aimed to longitudinally evaluate changes in zinc, copper, and iron levels in breastfed infants and their mothers during the first year of life. Serum and hair samples were obtained from 35 healthy breastfed infants (51 % males, 49 % females) and their mothers 2, 6, and 12 months after delivery. All of the samples were assessed using an atomic absorption spectrophotometer. Serum iron levels were determined by a Roche/Hitachi/Modular analyzer. Statistical analyses were performed using SPSS-PC (Version 21.00) software. Hair zinc (p < 0.05) and serum iron (p < 0.001) levels of infants were significantly decreased towards the end of the first year. Infants’ serum copper levels were increased towards the end of the first year. Maternal serum and hair copper levels and serum iron levels were significantly decreased towards the end of the first year. There were no significant correlations between dietary zinc, copper, iron intake, and trace element levels of infants and their mothers. Infants’ hair zinc levels, maternal and infants’ hair copper levels, and infants’ and maternal serum iron levels declined towards the end of the first year. Infants need more zinc after 6 months of age. Infants’ and mothers’ daily iron intake was less than the recommended intake.
  • References (48)
  • Citations (6)
📖 Papers frequently viewed together
14 Citations
3 Citations
12 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Daniel J Raiten (NIH: National Institutes of Health)H-Index: 16
#2Fayrouz A Sakr Ashour (NIH: National Institutes of Health)H-Index: 6
Last. Ben van OmmenH-Index: 1
view all 9 authors...
An increasing recognition has emerged of the complexities of the global health agenda-specifically, the collision of infections and noncommunicable diseases and the dual burden of over- and undernutrition. Of particular practical concern are both 1) the need for a better understanding of the bidirectional relations between nutritional status and the development and function of the immune and inflammatory response and 2) the specific impact of the inflammatory response on the selection, use, and ...
90 CitationsSource
#1Xuezhuang Wu (CAAS: Civil Aviation Authority of Singapore)H-Index: 4
#2Zhi LiuH-Index: 4
Last. Xiuhua GaoH-Index: 5
view all 8 authors...
An experiment was conducted in a 3 × 3 (Cu × Zn) factorial experiment based on a completely randomized design to evaluate the effects of dietary copper and zinc on apparent mineral retention and serum biochemical indicators in young male mink on a corn-fish meal based diet. Animals were fed basal diets supplemented with Cu from copper sulfate (CuSO4) and Zn from zinc sulfate (ZnSO4). Supplemental Cu levels were 0, 15, and 30 mg/kg copper, respectively, while supplemental Zn levels were 0, 150, a...
7 CitationsSource
52 CitationsSource
#1Q. ShaziaH-Index: 1
#2Z. H. MohammadH-Index: 1
Last. Hossain Uddin ShekharH-Index: 10
view all 4 authors...
Beta thalassemia major is an inherited disease resulting from reduction or total lack of beta globin chains. Patients with this disease need repeated blood transfusion for survival. This may cause oxidative stress and tissue injury due to iron overload, altered antioxidant enzymes, and other essential trace element levels. The aim of this review is to scrutinize the relationship between oxidative stress and serum trace elements, degree of damage caused by oxidative stress, and the role of antiox...
50 CitationsSource
#1Sathyaprasad Burjonrappa (Boston Children's Hospital)H-Index: 14
#2Malki Miller (Maimonides Medical Center)H-Index: 3
Abstract Background Parenteral nutrition (PN) has transformed the outcome for neonates with surgical problems in the intensive care unit. Trace element supplementation in PN is a standard practice in many neonatal intensive care units. However, many of these elements are contaminants in PN solutions, and contamination levels may, in themselves, be sufficient for normal metabolic needs. Additional supplementation may actually lead to toxicity in neonates whose requirements are small. Methods An e...
30 CitationsSource
#1Chia-Ni Lin (UofU: University of Utah)H-Index: 4
#2Andrew Wilson (ARUP Laboratories)H-Index: 14
Last. Gwendolyn A. McMillin (ARUP Laboratories)H-Index: 22
view all 6 authors...
Abstract Background Copper and zinc are essential trace elements and nutrients, which have important roles in physiology and disease and as cofactors in many metabolic pathways. We established age- and gender-specific reference intervals for serum copper and zinc, with a large healthy pediatric population. Methods A total of 2115 clinically healthy children, 85.4% Caucasian, were enrolled: 1098 boys and 1017 girls 0.5–18 y. Serum copper and zinc concentrations were measured by inductively couple...
19 CitationsSource
#1Gaetano Dongarra (University of Palermo)H-Index: 22
#2M. C. Lombardo (University of Palermo)H-Index: 14
Last. Giuseppina CuttittaH-Index: 20
view all 6 authors...
Trace element contents in specimens of hair collected from 137 children aged 11–13 years old, living in Palermo (Sicily, Italy) were determined by ICP-MS. This work reports analytical data for the following 19 elements: Al, As, Ba, Cd, Co, Cr, Cu, Li, Mn, Mo, Ni, Pb, Rb, Sb, Se, Sr, U, V and Zn. The most abundant chemical elements were zinc and copper (Zn > Cu), with concentrations exceeding 10 μg/g (Zn = 189.2 μg/g; Cu = 22.9 μg/g). Other elements with concentrations greater than 1 μg/g were, i...
59 CitationsSource
#1Amal A HegazyH-Index: 1
Last. Raya A SalehH-Index: 1
view all 5 authors...
Background Anemia is a health problem among infants and children. It is often associated with a decrease in some trace elements (iron, zinc, copper) and an increase in heavy metals as lead. This study was done to determine the association of blood lead level > 10 μg/dl, with the increased risk to anemia, also, to investigate the relationship between anemia and changes in blood iron, zinc and copper levels, and measure lead level in drinking water. The study is a cross-sectional performed on 60 c...
60 CitationsSource
#1Irene Voskaki (Boston Children's Hospital)H-Index: 1
#2Vasiliki Arvanitidou (DUTH: Democritus University of Thrace)H-Index: 5
Last. Aglaia Giannoulia-Karantana (Boston Children's Hospital)H-Index: 8
view all 6 authors...
The aim of this study was to investigate whether there is a correlation between copper (Cu) and zinc (Zn) levels in children and their parents, considering their nutritional habits. Cu and Zn concentrations were measured by flame atomic absorption spectrophotometry in the serum of 66 healthy children, aged 3–14 years, and their parents, residing in a region of Greece (Thrace). Cu levels were higher in mothers than those in fathers, but they were lower in both parents than those in children. They...
13 CitationsSource
#1Ariane Bruder-Nascimento (UNESP: Sao Paulo State University)H-Index: 6
#2Carlos Henrique Ribeiro Camargo (UNESP: Sao Paulo State University)H-Index: 20
Last. Eduardo Bagagli (UNESP: Sao Paulo State University)H-Index: 26
view all 7 authors...
Background: Species identification and antifungal susceptibility tests were carried out on 212 Candida isolates obtained from bloodstream infections, urinary tract infections and dialysis-associated peritonitis, from cases attended at a Brazilian public tertiary hospital from January 1998 to January 2005. Findings: Candida albicans represented 33% of the isolates, Candida parapsilosis 31.1%, Candida tropicalis 17.9%, Candida glabrata 11.8%, and others species 6.2%. In blood culture, C. parapsilo...
148 CitationsSource
Cited By6
Optimized nutrition during the first 1000 days (from conception through the 2nd birthday) is critical for healthy development and a healthy life for the newborn. Pregnancy and the postpartum period are accompanied by physiological changes, increased energy needs, and changing requirements in the nutrients critical for optimal growth and development. Infants and toddlers also experience physiological changes and have specific nutritional needs. Food and nutrition experts can provide women of chil...
#1Gurseen Rakhra (Defence Institute of Physiology and Allied Sciences)H-Index: 1
#2Daisy Masih (Defence Institute of Physiology and Allied Sciences)H-Index: 1
Last. Som Nath Singh (Defence Institute of Physiology and Allied Sciences)H-Index: 16
view all 6 authors...
From the time of dietary intake to their utilization, the number of important interactions occurs among mineral elements, which can affect their bioavailability because of similarity in physicochemical properties and common absorptive pathways. However, the studies that have analyzed the interactions among copper, iron, and zinc have conflicting results and need further exploration. HT-29 cells grown to confluence in 6-well plates were incubated with increasing concentrations (0 to 200 μM) of Cu...
#1Hatice Yorulmaz (Haliç University)H-Index: 4
#2Elif Ozkok (Istanbul University)H-Index: 12
Last. Sule Tamer (Istanbul University)H-Index: 6
view all 7 authors...
AbstractThere are a number of studies investigating anti-inflammatory effects of simvastatin in patients with sepsis and animal models. There are a few studies which investigated effect of simvasta...
#1Silvia MagginiH-Index: 10
#2Adeline PierreH-Index: 1
Last. Philip C. CalderH-Index: 105
view all 3 authors...
As humans age, the risk and severity of infections vary in line with immune competence according to how the immune system develops, matures, and declines. Several factors influence the immune system and its competence, including nutrition. A bidirectional relationship among nutrition, infection and immunity exists: changes in one component affect the others. For example, distinct immune features present during each life stage may affect the type, prevalence, and severity of infections, while poo...
10 CitationsSource
#1Rafał Kocyłowski (Memorial Hospital of South Bend)H-Index: 5
#2Iwona LewickaH-Index: 3
Last. Joanna SuliburskaH-Index: 16
view all 8 authors...
Purpose To evaluate the dietary intake of pregnant women and their nutritional status of Ca, Mg, Fe, Zn, and Cu, as the nutritional status of pregnant women is an important factor for the proper progression of a pregnancy and the development and health of the foetus.
3 CitationsSource
#1Tong Zhou (CAS: Chinese Academy of Sciences)H-Index: 3
#2Zhu Li (CAS: Chinese Academy of Sciences)H-Index: 15
Last. Peter Christie (CAS: Chinese Academy of Sciences)H-Index: 56
view all 5 authors...
ABSTRACTConcentrations of copper (Cu) and zinc (Zn) were determined in 383 human hair samples and in 445 food samples purchased in 11 Chinese cities. The concentrations of Cu were 7.91, 5.39, 2.27 and 2.20 mg kg−1 and those of Zn were 47.2, 24.8, 52.8 and 30.2 mg kg−1 in vegetables, cereals, meat and fish, respectively. The overall mean concentrations of hair Cu and Zn were 8.97 and 128 mg kg−1, respectively. Hair Cu and Zn concentrations were higher in females than in males, especially in the 1...
3 CitationsSource
#1M. Leigh Ackland (CCMB: Centre for Cellular and Molecular Biology)H-Index: 19
#2Agnes Michalczyk (CCMB: Centre for Cellular and Molecular Biology)H-Index: 17
Zinc is essential for a wide variety of cellular processes in all cells. It is a critical dietary nutrient, particularly in the early stages of life. In the early neonatal period, adequate sources of zinc can be obtained from breast milk. In rare circumstances, the mammary gland produces zinc deficient milk that is potentially lethal for exclusively breast-fed infants. This can be overcome by zinc supplementation to the infant. Alterations to key zinc transporters provide insights into the mecha...
14 CitationsSource