Denoising DNA deep sequencing data—high-throughput sequencing errors and their correction
Abstract
Characterizing the errors generated by common high-throughput sequencing platforms and telling true genetic variation from technical artefacts are two interdependent steps, essential to many analyses such as single nucleotide variant calling, haplotype inference, sequence assembly and evolutionary studies. Both random and systematic errors can show a specific occurrence profile for each of the six prominent sequencing platforms surveyed here:...
Paper Details
Title
Denoising DNA deep sequencing data—high-throughput sequencing errors and their correction
Published Date
May 29, 2015
Journal
Volume
17
Issue
1
Pages
154 - 179
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