Reconsidering the Role of Mitochondria in Aging

Background: Mitochondrial dysfunction has long been considered a major contributor to aging and age-related diseases. Harman’s Mitochondrial Free Radical Theory of Aging postulated that somatic mitochondrial DNA mutations that accumulate over the life span cause excessive production of reactive oxygen species that damage macromolecules and impair cell and tissue function. Indeed, studies have shown that maximal oxidative capacity declines with...