Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein
Abstract
Plasmodium falciparum engineer infected erythrocytes to present the malarial protein, VAR2CSA, which binds a distinct type chondroitin sulfate (CS) exclusively expressed in the placenta. Here, we show that the same CS modification is present on a high proportion of malignant cells and that it can be specifically targeted by recombinant VAR2CSA (rVAR2). In tumors, placental-like CS chains are linked to a limited repertoire of cancer-associated...
Paper Details
Title
Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein
Published Date
Oct 1, 2015
Journal
Volume
28
Issue
4
Pages
500 - 514
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Notes
History