A novel ligand conjugated nanoparticles for oral insulin delivery

In order to enhance the interaction between nanocarrier and gastrointestinal epithelial cells, we developed nanoparticles (NPs) modified with targeting ligand FQSIYPpIK (FQS), which specifically interact with integrin αvβ3 receptor expressing on the intestinal epithelium. The targeting NPs were prepared by coating the insulin-loaded poly(lactide-co-glycolide)–monomethoxy-poly(polyethylene glycol) micelle cores with FQS modified trimethyl...