Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.

Volume: 36, Issue: 48, Pages: 3404 - 3412
Published: Dec 21, 2015
Abstract
Sirtuins (Sirt1–Sirt7) comprise a family of nicotinamide adenine dinucleotide (NAD+)-dependent enzymes. While deacetylation reflects their main task, some of them have deacylase, adenosine diphosphate-ribosylase, demalonylase, glutarylase, and desuccinylase properties. Activated upon caloric restriction and exercise, they control critical cellular processes in the nucleus, cytoplasm, and mitochondria to maintain metabolic homeostasis, reduce...
Paper Details
Title
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.
Published Date
Dec 21, 2015
Volume
36
Issue
48
Pages
3404 - 3412
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