High-fat diet caused widespread epigenomic differences on hepatic methylome in rat
Abstract
A high-fat (HF) diet is associated with progression of liver diseases. To illustrate genome-wide landscape of DNA methylation in liver of rats fed either a control or HF diet, two enrichment-based methods, namely methyl-DNA immunoprecipitation assay with high-throughput sequencing (MeDIP-seq) and methylation-sensitive restriction enzyme sequencing (MRE-seq), were performed in our study. Rats fed with the HF diet exhibited an increased body...
Paper Details
Title
High-fat diet caused widespread epigenomic differences on hepatic methylome in rat
Published Date
Oct 1, 2015
Journal
Volume
47
Issue
10
Pages
514 - 523
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