Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes.
Abstract
Flavonoids are widely occurring in our diet. In this study, the effects of nine flavonoids on acetaminophen (APAP) oxidation and related cytochrome P450 (P450) enzyme activities were investigated. With rat liver microsomes, APAP oxidation was stimulated 2- to 4-fold by 50 microM flavone or tangeretin and inhibited 65% by myricetin or quercetin. Only a slight inhibition of APAP oxidation was caused by naringenin. All the effects cited herein were...
Paper Details
Title
Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes.
Published Date
Jul 1, 1994
Journal
Volume
22
Issue
4
Pages
566 - 71
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History