A computational method for resequencing long DNA targets by universal oligonucleotide arrays

Volume: 99, Issue: 24, Pages: 15492 - 15496
Published: Nov 12, 2002
Abstract
Universal arrays contain all possible oligonucleotides of a certain length, typically 6-10 bases. They can determine in a single experiment all substrings of that length that occur along a target sequence. That information, also called the spectrum of the sequence, is not sufficient to uniquely reconstruct a sequence longer than a few hundred bases. We have devised a polynomial algorithm that reconstructs the sequence, given the spectrum and an...
Paper Details
Title
A computational method for resequencing long DNA targets by universal oligonucleotide arrays
Published Date
Nov 12, 2002
Volume
99
Issue
24
Pages
15492 - 15496
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