SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling

Volume: 191, Issue: 2, Pages: 892 - 901
Published: Jul 15, 2013
Abstract
Recognition of microbial products by TLRs is critical for mediating innate immune responses to invading pathogens. In this study, we identify a novel scaffold protein in TLR4 signaling called SAM and SH3 domain containing protein 1 (SASH1). Sash1 is expressed across all microvascular beds and functions as a scaffold molecule to independently bind TRAF6, TAK1, IκB kinase α, and IκB kinase β. This interaction fosters ubiquitination of TRAF6 and...
Paper Details
Title
SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling
Published Date
Jul 15, 2013
Volume
191
Issue
2
Pages
892 - 901
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